Pharmacokinetics / Toxicokinetics

Preclinical Toxicokinetic/Pharmaceutics Research – Lovelace Biomedical has broad capabilities for determining the absorption, distribution, metabolism, and excretion of drug entities delivered by all exposure routes. Lovelace excels in the development and use of novel delivery, tracer, and analytical approaches to resolve dosimetric and metabolic questions. We combine leading-edge bioanalytical chemistry and radioanalytical capabilities with expertise in exposure, biochemistry, toxicology, and pathology to optimize the pharmaceutical efficacy and select laboratory species most predictive of human responses.

Clinical Pharmacokinetics And Toxicokinetics Research
  • Complete range of dose-delivery modes: oral, intravenous, bolus, infusion
  • Complete range of laboratory animal species
  • Analysis of compound and metabolites in biological samples by LC-MS/MS and other modalities
  • Radioisotope studies: conduct of ADME studies in rodent and non-rodent species
  • Distribution of radiotracers by gamma scintigraphy, autoradiography, and radiochemical analyses
  • Iterative mathematical modeling of pharmacokinetics
  • Extrapolation of human pharmacokinetics using physiologically based pharmacokinetics (PBPK) modeling
  • PK/PD modeling and regimen design