Preclinical Toxicokinetics and Pharmacokinetics

Lovelace Biomedical’s mission is to advance biomedical research for the benefit of our pharmaceutical and biotechnology partners. We’re leveraging a multidisciplinary toolset that allows us to push the limits of our preclinical research while streamlining our customer’s experience. As leaders in the industry, our organized structure allows us a quick turnaround on proposals and contracts, as we adapt to our client’s needs.

Toxicokinetics vs. Pharmacokinetics

One of the most vital parts of our research is a focus on preclinical toxicokinetics (TK) and pharmacokinetics (PK). Toxicokinetic data is driven by the use of bioanalytical sampling in order to characterize dispositions of a target compound in the process of drug absorption, distribution, metabolism, and excretion in an organism. Toxicokinetic’s goal is to research and define a subject’s exposure to various chemicals and the outcome of dose level and time administered in the body. Pharmacokinetics relies on factors regarding a patient’s history when administered a drug or chemical. Pharmacokinetics expands on a drug’s chemical properties, half-life, how it is metabolized within an individual, and how their history can have an effect on drug outcome.

Lovelace Biomedical is ready to partner with you in preclinical toxicokinetics and pharmacokinetic studies. We serve a variety of scientific industries and practices in Albuquerque, New Mexico, as well as nationally and internationally. We’re the industry leader in preclinical toxicokinetic and pharmacokinetic research.

Toxicokinetic and Pharmacokinetic Processes

Toxicokinetics and pharmacokinetics both involve four processes, which are:

  • Absorption
  • Distribution
  • Biotransformation
  • Excretion

The first process, absorption, is where the administration of a drug or chemical enters the body. Distribution focuses on the site of entry and how a drug or chemical moves about the body, as well as the rate of movement. Biotransformation involves the way in which the body takes the drug or chemical administered and metabolizes it into new chemicals that are beneficial to the body. Finally, excretion is how the newly metabolized chemical exits the body and what method the body takes to excrete the chemicals.

Lovelace Biomedical, Leaders of the Industry

Located in Albuquerque, New Mexico, Lovelace Biomedical is equipped with experienced and knowledgeable scientists and researchers that are ready to handle a variety of preclinical programs. We’re trusted for our research in both toxicokinetics and pharmacokinetic research and get results for our clients through our complete range of dose-delivery modes, from oral, and intravenous, to bolus, and infusion. Our expansive 300,000 sq.ft. lab allows us the space necessary to properly research and obtain results in all our preclinical trials.

To inquire about partnering with Lovelace Biomedical, or to learn more about the work we do, please contact us online.

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