Bioanalytical / Analytical Chemistry


Lovelace Biomedical has extensive expertise in preclinical bioanalytical chemistry research, with specialized laboratories and experienced bioanalytical method development/validation and sample analysis chemists. Whether working with a small molecule, or qPCR bioanalysis Lovelace has experience developing new assays or transferring existing methods. These methods can support pharmacokinetic, toxicokinetic, biodistribution, and in vivo metabolism studies. The analyses can be conducted to evaluate parent molecules or metabolites in a full range of matrices, including blood, plasma, serum, urine, CSF, pleural fluid, and tissue. Whether your study is an exploratory research study or a GLP toxicology study Lovelace has the Bioanalytical team to support your needs. preclinical biomedical research and preclinical biotechnology research teams also can support you from Lovelace Biomedical.

Our Analytical/Bioanalytical Chemistry Department provides a state-of-the-art infrastructure with experience in chromatography, and mass spectrometry. Lovelace has the experience and tools required to develop, transfer and validate methods on small molecules, proteins or peptides to support PK/TK and metabolism studies. Analyses can be conducted to assay concentrations of parent molecules or compounds in a full range of matrices including blood, plasma, serum, urine and tissue.

Bioanalytical Fact Sheet: Download

  • Parent molecule analysis
  • Metabolism characterization
  • Development/transfer of bioanalytical assays
  • Validation of methods
  • GLP compliance
  • Novel/complex assay development capabilities
    • Multiple analytes
    • Endogenous analytes
  • Mass spectrometer systems
    • Sciex 5500 – Shimadzu UPLC
    • Sciex 5000 – Waters/Shimadzu UPLC
    • Sciex 4500 – Shimadzu UPLC
    • Sciex 4000 – Waters UPLC
  • HPLC
    • Agilent 1100 / 1200; DAD, VWD, RID, FLD detectors
    • UPLC Acquity: PDA, FLD, ECD detectors
  • Gas chromatography
    • Agilent 7980/6980 with MS/FID/ECD/TCD detectors
  • Spectrophotometers
  • Molecular Devices and Biotek plate readers
  • Quantitative PCR – Bio-Rad CFX 384s
  • MSD QuickPlex SQ 120
  • Tecan / Eppendorf Liquid Handlers
  • TomTec Quadra Extraction System
  • KingFisher Flex Purification System
  • Molecular Devices and Biotek plate readers
  • Quantitative PCR – Bio-Rad CFX 384s
  • Planetary Ball Mill
  • Jet Air Mill
  • Solid State Analysis
    • TA Instruments TGA
    • Thermo FTI

Key Capabilities

  • Method Transfer
  • Method Development
  • Method Validation per FDA/EMA


Mass Spectometer Systems

  • Sciex API 4000, 5000, 4500, and 5500’s. All with uHPLC’s

Gas Chromatogrophy

  • Agilent 7890 and 6890, MS, TCD & ECD detectors, liquid and head autosampler

Liquid Chromatogrophy

  • Agilent 1100/1200, MS; DAD, VWD, RID, FLD detectors
  • Waters Acquity UPLC equipped with PDA; FLD, ECD detecros

ELISA Systems

  • Luminex MagPix
  • Molecular Diagnostics i3x Plate Reader

Tecan/Eppendorf Liquid Handlers TomTec Quadra Extraction System Quantative PCR

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