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Lovelace Biomedical Staff Spotlight – Dharmesh Desai, PhD

Welcoming and Learning About Lovelace Biomedical’s New Director of Immunology & Large Molecule Bioanalysis Dharmesh, give us a little background on yourself. My background is in cellular immunology, and the bulk of my career post-academia has been in the bioanalytical space, mostly in large molecule biologics. I have worked with a number of antibody, protein […]

Blog: Hammad Irshad – Using a Degree in Engineering to Make a Difference in Public Health

Staff Spotlight: Hammad Irshad, Research Scientist at Lovelace Biomedical. Hammad has 18 years experience, and focuses on our aerosol development and delivery for novel therapies. Hammad, tell me what you do as an aerosol scientist at Lovelace. Overall, my work leverages Lovelace’s broad capabilities in aerosol science to answer important questions that improve public health and regulations. […]

From Our Blog: PCR Development, it’s Uses, and Important Research at Lovelace Biomedical, with Bryan Gullick, PhD, Bioanalytical Research Scientist

Staff Spotlight: Bryan Gullick, PhD, Research Scientist Bryan, tell us about PCR in the development and conduct of pharmacology and toxicology studies PCR assay development closely follows the in vivo studies required to support an IND. Along this path from pharmacology to toxicology the scientific team reviews, and evaluates what species to utilize. They will consider […]

Blog: Preclinical Drug Development for a Gene Therapy Product: No Cookie Cutter Route

Preclinical Drug Development for a Gene Therapy Product: No Cookie Cutter Route   Follow these critical steps on your path to IND application. By Philip J. Kuehl, PhD, Senior Scientist and Director of Scientific Core Laboratories, Lovelace Biomedical and Jacob D. McDonald , PhD, Senior Scientist and Chief Scientific Officer, Lovelace Biomedical Cell and gene therapy […]

Blog Post – 2020: The Year of the Scientist

  was the year of the scientist. In a culture where we primarily celebrate the accomplishments of artists or the affluent, this year we celebrated the accomplishments, knowledge and capabilities of scientists and, in a sense, science. It is always fun to be working on research that is topical to the well-being of humankind. This […]

Lovelace Biomedical Staff Spotlight: Tracylyn Yellowhair – Intra-tracheal (IT) Atomization of IT Liquid Delivery of a Test Article

As translational researchers we’re faced with many challenges in determining the best routes and methods for delivering inhaled therapeutics that will allow for precise targeted dosing and maximum benefit to the patient, especially now with the ongoing COVID-19 pandemic. Thus, we aimed to delineate some of this complexity by comparing the pulmonary distribution of a […]

From our Blog: Expert Pre-Clinical Toxicology – There is No Standard Template!

2019’s ACT meeting in Phoenix, AZ was the 40th Annual Meeting and brought some key highlights to the Lovelace Biomedical team. In addition to catching up with colleagues, scientists and business development team members had the opportunity to attend continuing education courses and scientific sessions in toxicology. In reviewing highlights with the scientific staff, several […]

Are You Getting The Most out of Your Scientific Meeting Attendance?

Thinking about Scientific and professional development. As I reflect upon 2019 and the different trade shows I attended over 2019, it was an interesting year, with one show standing out for something other than scientific content. As the pharmaceutical industry has shifted over the last 10 years with travel budgets severely restricted since 2008, most […]

Lovelace Biomedical Staff Spotlight: Janet Benson, Senior Scientist

Highlighting our excellent staff at Lovelace Biomedical   Today’s staff spotlight belongs to Janet Benson. Janet is one of Lovelace’s longest tenured scientist, with decades of experience and also one of the most respected and well-known leaders in the gene therapy space. Here, Janet gives us a little glimpse into her career, inspiration, and interests. […]

Post Meeting Thoughts from the North American Cystic Fibrosis Conference (NACFC)

It was reinvigorating to get out from behind the desk, and out of the lab this past weekend to attend the 2019 NACFC in Nashville. First, a couple of admissions – I was only able to attend the last day and a half of the meeting, and this was my first time attending this one […]

Traumatic Brain Injury – Collaborative Translational Science at Lovelace Biomedical and the Mind Research Network

Traumatic Brain Injury (TBI) is just one of the many areas of scientific study Lovelace Biomedical, along with its sister company the Mind Research Network (MRN), has in its repertoire.  Dr. Andy Mayer, Professor of Translational Neuroscience at MRN is studying mild TBI, with the goal of improving diagnosis and treatment of cognitive deficits following […]

Lovelace Biomedical Staff Spotlight: Adam Werts – Veterinary Research Scientist

Highlighting our excellent staff at Lovelace Biomedical Today, we put the spotlight on Adam Werts. Adam recently joined Lovelace Biomedical as part of our veterinary research team. Adam gives us an insight to his life, his career, and what he’s up to since joining Lovelace Biomedical. Bio:  I spent the first twenty-two years of my […]

RT-PCR Validations: Square Peg/Round Hole?

Jacob McDonald, CSO – Lovelace Biomedical I set a disclaimer right away, in that I have been called a jack of all trades, and lately, a master of probably none (don’t tell my kids). I have been pontificating over the past couple of years on the quandary of quantitative PCR for support of Gene Therapy […]

Updating My Business Plan for Competitive Landscape in the CRO Industry – What a Task!

– Jacob McDonald, CSO – Lovelace Biomedical Last summer, I wrote a business plan for Lovelace Biomedical. It aimed at continuing to focus our energy on expanding our preclinical services business. Recently, I was looking to update the business plan and was taken aback at just how much I had to revisit the story about […]

“Beyond Standing Room Only” – Thoughts on the 22nd Annual Meeting of the Society of Gene and Cell Therapy – Dr. Janet Benson

As someone who has watched the ASGCT conference grow fairly steadily over the last 11 years, the growth in meeting attendance and vendor presence between 2018 and 2019 is nothing short of stunning. It was not uncommon in the past few years to need to stand during sessions to hear presentations, but never before has there […]

Lovelace’s Director of Bioanalytical Operations, Larry Mallis to be on hand to present poster at ASMS 2019 annual conference

Novel bioanalytical approaches to drug development – 5-AZA a case study to be presented at the 67th ASMS Conference in Atlanta Within drug development, the quantitation of drug levels within the systemic circulation and target tissues can provide insight into tolerance and / or efficacy. For small molecules the mainstay for quantitative analysis is LC-MS/MS. […]

Lovelace Biomedical Talks About Developing Novel Therapies for Cystic Fibrosis Month

May is Cystic Fibrosis (CF) month. Lovelace has been working in respiratory research for over 70 years, and has been using gene therapy studies to develop drugs to treat CF and other similar diseases for over 10 years. As a part of CF month, Lovelace’s expert scientists, Ted Barrett and Philip Kuehl are here to […]

BIOCHEMISTRY

Biochemistry or biological chemistry is a branch of biology and chemistry involving intense study of different chemical processes taking place inside living organisms. These biochemical processes are notably the fundamental reasons for complexity of life. Biochemistry is classified into molecular genetics, metabolism and protein science. It figures out the way in which bio molecules give […]

BIOINFORMATICS

Bioinformatics involves in-depth understanding of biological data through strategic development of appropriate software tools. This is an interdisciplinary field including computer science, biology, mathematics, statistics, and information engineering all of which are essential to comprehend with abstract biological information. Bioinformatics has many different applications such as silico analysis for biological queries, candidate gene identification, SNP […]

CELL BIOLOGY

Cell biology is the intense study of structure, composition, physiology and functioning of cells which is the most fundamental unit of any living organism. This understanding of cellular components and their functioning forms the basic for all biological sciences. Cell Biology deeply understands and analyzes the physiological processes, lifecycle, chemical properties, metabolism, and interactions between […]

DRUG DESIGN

Preclinical Drug Design or Rational Drug Design is the process of discovering medications. The process of drug design is carried out only upon obtaining a thorough understanding of the biological target. The drug thus developed is a molecule aimed at having therapeutic effects on the patient it is injected on. This drug performs either by […]

MOLECULAR BIOLOGY

Molecular Biology is a branch of biology that understands and analysis the molecular structure, composition and functioning of cellular molecules. It deals with different disciplines including biology, chemistry, genetics and biochemistry. In other words, molecular biology strives to understand how genes get transcribed to RNA which in turn gets transcribed as proteins. In this process, […]

PHARMACEUTICS

Pharmaceutics is one of the divisions of pharmacy. It involves dealing with New Chemical Entities or drugs that are safely transformed and used on patients as medication. There are numerous chemicals having pharmacological properties, but cannot be directly used on patients. By performing special procedures, these chemicals can easily be transformed into medicines of therapeutic […]

SCIENTIFIC RESEARCH

Scientific research is the sequential process of data collection, interpretation, analysis and reporting done in order to make contributions to scientific developments. It basically involves data assimilation from a group of volunteers to figure out the reasons of diseases, its developmental phases and effects so that it aids in developing newer diagnostic methods and treatments […]

PRECLINICAL RESEARCH

Preclinical research also known as preclinical study or preclinical development is the phase of research conducted prior to clinical trials. It is a type of non-clinical study where drug-related data are carefully sourced and compiled in order to gain deep understanding of its feasibility of use on humans and product safety profile. Preclinical research mainly […]

TOXICOLOGY

Preclinical Toxicology Research – Toxicology is the process of analyzing and understanding the effects of toxic chemical substances when injected into any living organism. It is the integration of chemistry, medicine, biology, and pharmacology. Toxicology also involves the study of different diagnostic processes and treatments offered for health hazards that result due to toxic exposure. Toxicology […]

BIOTECHNOLOGY

Biotechnology is an extensive part of biology involving the development of technically advanced tools and techniques for use in biological systems in order to uplift overall quality standards of living. Biotechnology involves the use of lot of different technologies, equipment, and tools based on which it can further be classified as genetic engineering, bionics, bio […]

Q & A with Audrey Yarbrough, Lovelace’s Senior Quality Assurance Specialist

Audrey will be attending and presenting at the 35th Annual Society of Quality Assurance Conference in Atlanta, GA April 28 – May 03. Read below as she answers questions to her job, her experience, the conference, and all things quality assurance. Tell me about the Importance of this event, and why is it important to […]

The FDA’s Guidance for Industry on Bioanalytical Method Validation, and us.

My thoughts, post WRIB annual conference – Larry Mallis, Director of Bioanalytical Operations At the recent WRIB meeting, my friends and colleagues in the bioanalytical community discussed the past year,  and our place in the biomedical industry. The topic in the spotlight was that the FDA’s “Bioanalytical Method Validation Guidance for Industry” was finalized and released […]

Who Are You Anyways?

Just a short while back I was in my final stretch of a marathon 31 meetings at the annual Society of Toxicology (SOT) meeting. It had been a frenzied meeting for me. It was the first time I have had that many meetings in the 19 years I had been coming to SOT. As I […]

Not bigger, just better…

Holy cow, it is embarrassing to think that when I was a kid we had that slogan printed on our high school football team t-shirts. I guess it worked, as we usually won, even if we were not the biggest or most talented team. I was thinking about slogans and marketing type things the other […]

Is There a Place for “Mom & Pop” Toxicology Laboratories?

I always thought that a Mom-and-Pop designation best fit a small bakery or perhaps a hardware store.  Sort of like “Cheers,” it’s “the place you want to go where everybody knows your name.” Never in my wildest dreams did I anticipate its use to describe a Toxicology laboratory, much-less Lovelace Biomedical. I remember when I […]

Gene Therapy Saved Me – Lovelace Biomedical’s CSO recalls what gene therapy research has done not only for the company, but for himself as well

Gene Therapy Saved Me. I mean, not literally…but certainly from a figurative standpoint. In 2016 I took on the task or rebranding Lovelace Biomedical from the Lovelace Respiratory Research Institute. The company had a long history of performing Gene Therapy and other Regenerative Medicine programs. But nobody but us knew it! In fact, we were […]

THE PATH TO NEW GENE THERAPY: 7 Steps to IND

An increasing number of pharmaceutical and biotech companies are seeking expert help to navigate investigational gene therapies through preclinical studies

Putting the Science First – Dr. Jacob McDonald

Our CSO, Dr. Jacob McDonald discusses the evolving CRO market, emerging trends in preclinical research and how Lovelace keeps innovation at the forefront. Putting the Science First Tweet!function(d,s,id){var js,fjs=d.getElementsByTagName(s)[0],p=/^http:/.test(d.location)?'http':'https';if(!d.getElementById(id)){js=d.createElement(s);js.id=id;js.src=p+'://platform.twitter.com/widgets.js';fjs.parentNode.insertBefore(js,fjs);}}(document, 'script', 'twitter-wjs');

Q & A With Dr. Meghan Vermillion, DVM – Who will be speaking at the 2019 ASM Biothreats Conference about Infectious Diseases

Catch Lovelace’s Dr. Meghan Vermillion speaking at the 2019 ASM Biothreats annual conference, which is happening January 29-31. We sat down with her to dive into her passions, what she thinks about her role, and what she is looking forward to at Lovelace. Click below

Lovelace Expands Veterinary Expertise with New Hires

Top veterinary talent is at the core of preclinical success. And the more complex the study, the more important that talent becomes. With this as a driving principle, Lovelace has made several key veterinary hires in recent months — growing its expertise for multifaceted studies and ensuring that animals at Lovelace receive the best care […]

A Culture of Continuous Improvement: The Lovelace Approach to Quality

The best-run preclinical research programs are just as devoted to strong science and achieving experimental objectives as they are to adhering to Good Laboratory Practice standards and other essential regulations that govern the industry. After all, without meeting the strict protocols of the FDA, USDA and numerous other oversight organizations, a drug’s preclinical development program […]

Lovelace Discovers Novel Approach to Overcome Limitations of Nucleoside Assays

Nucleoside analogues are an essential component of many chemotherapies, anti-bacterial drugs and anti-viral agents. These compounds can play a key role in heightening therapeutic effects and, in the case of cancer treatments, leading to cell death. Of the nucleoside analogues in development, 5-azacytidine is being studied as a targeted therapy for lung cancer, as it [...]

Focus on Infectious Disease: Reducing the Threat of ‘Flu-Imposter’ Adenovirus

It may feel like the flu — and be just as grave of a health threat — but it’s not the flu. It’s adenovirus, an infectious disease that often goes undetected because it presents itself almost identically to influenza. Symptoms for both diseases include fever, headache and body aches. Both are highly contagious and spread […]

Lovelace’s Novel Nucleoside LCMS Assay to Be Presented at 12th Workshop on Regulations in Bioanalysis

Increasingly, biopharmaceutical companies are developing nucleoside analogues as chemotherapeutic, anti-bacterial and anti-viral agents. Of the nucleoside analogues in development, 5-azacytidine is being studied as a targeted therapy for lung cancer, as it may be able to amplify the therapeutic agent at the site of action while reducing off-site toxicities. Sensitive and selective bioanalytical assays allow [...]

The Tox Factor: 4 Tips for Drug Sponsors Seeking a Toxicology Partner

Toxicology is often called the “science of safety,” and for good reason. The field is essential in moving potential new drugs from the lab to the clinic, enabling drug sponsors to predict whether any components of the drug may cause harm to patients. And if a chemical is deemed harmful, toxicologists can figure out why.

Existing Molecules Find New Calling as Medical Countermeasures

Innovation is percolating around new approaches to treating injuries that result from chemical, biological, radiological and nuclear defense, as well as other public health emergencies. With funding from BARDA and other government entities, commercial pharmaceutical and biotechnology firms are seeking to repurpose existing molecules to save more lives.

Old Drug, New Tricks: Lovelace Paves Fresh Path for Approved Cancer Therapy

The established cancer drug topotecan may hold promise as a more targeted therapy for patients with small-cell lung cancer (SCLC), according to the results of a study presented by Lovelace Biomedical scientists. The findings are significant, as lung cancer remains one of the leading causes of cancer deaths worldwide. New treatment options are direly needed, […]

Animal Behavioral Management Is Core to Preclinical Success

For preclinical pharmacology and toxicology studies to succeed, it’s essential that investigators and their teams use best practices for animal enrichment and environmental enhancement. Animal stress — which can stem from lack of trust in the researchers or an inability to express natural, species-specific behaviors — can compromise study data.

The Less Cough, the Better: Lovelace Biomedical, Novartis Research Collaboration Aims to Improve Inhaled Drugs

Inhaled medicines play an essential role in treating respiratory conditions and many other diseases, from pulmonary fibrosis to asthma. However, a dose of inhaled medicine often results in a cough — an adverse reaction that can be both uncomfortable and counterproductive. It’s a reaction that drug developers seek to avoid as they develop the next […]

Lovelace Research Spotlight: Aerosol-Delivered Gene Therapy for Cystic Fibrosis

In a key study published in Human Gene Therapy Clinical Development, Lovelace Biomedical researchers found that delivering AAV gene therapy for cystic fibrosis by inhalation was both feasible and safe.

Nose-Only Inhalation of microRNA Shows Promise for Pulmonary Fibrosis

Lovelace Biomedical designed a nose-only inhalation exposure system to evaluate an investigational microRNA-based therapy for pulmonary fibrosis — and through its findings, has helped to further advance a novel approach to treating a long-underserved disease.

Overcoming Preclinical Hurdles in Rare Disease Research

For pharmaceutical and biotech companies, rare diseases present huge market opportunities — but also, potentially daunting development challenges. Incentivized by the market exclusivity promised by the Orphan Drug Act, drug companies are further bolstered by recent scientific advancements that have improved our biological understanding of many rare diseases. Today, it is possible to target traditionally [...]

qPCR: The Weapon of Choice for Gene and Cell Therapy Biodistribution

To advance a gene or cell therapy product into clinical trials, drug developers must first gain a thorough understanding of how the agent travels through the body and to the target (or off-target) organs. Beyond this, qPCR can be used to evaluate vector shedding of gene therapies in body fluids and excreta, and provide a [...]

Lovelace Radiation Research in the Spotlight at National Convention

Lovelace Biomedical’s scientific team will share two recent examples of their advanced preclinical work in defining animal models for radiation research at the upcoming Radiation Research Society’s annual meeting, Oct. 15-18 in Cancun, Mexico. Both of the studies to be presented were completed under contract with the U.S. government’s Biomedical Advanced Research and Development Authority [...]

The Tools and Talent to Investigate the Flu: A Unique CRO Capability

It was nearly a century ago, in 1918, that an influenza pandemic swept the world, killing as many as 40 million people. The “Spanish Flu,” as it was known, ended up causing nearly 675,000 deaths in the U.S., as it was a strain that quickly converted to pneumonia at a time when antibiotic drugs weren’t [...]

FEATURED WEBINAR: Innovation in Aerosol Drug Formulations

Get an inside look into a 15-year collaboration between the scientists at Lovelace Biomedical and engineers at Capsugel, a company that develops and manufactures dosage forms for the biopharmaceutical and consumer health industries. After Capsugel created an aerosol drug formulation using spray-drying and encapsulation technologies, it was up to Lovelace to identify clinically relevant in [...]

Breathe Easy: Meeting the Preclinical Challenges of Pulmonary Fibrosis

The race is on for better therapies to treat pulmonary fibrosis, a chronic lung disease characterized by irreversible scarring of lung tissue. Though the condition is classified as a rare disease, its impact on patients is profound: nearly as many Americans die each year from the most common form of the disease, idiopathic pulmonary fibrosis […]

Lovelace Biomedical Featured in The Scientist: Why Pharma Should Consider Canine Models for Alzheimer’s

The Scientist magazine recently featured an opinion article from Lovelace Biomedical Senior Scientist Edward Barrett, Ph.D., who shared his research that suggests canine models may offer the best preclinical outcomes for investigational therapies to treat neurodegenerative diseases. Dr. Barrett explains the drug industry’s challenge to meet clinical endpoints for Alzheimer’s therapies that have shown promise [...]

Lovelace Biomedical’s Advances in Toxicological Research to be Featured at the 56th Annual Meeting of the Society of Toxicology

Albuquerque, N.M., March 8, 2017 – Lovelace Biomedical, a not-for-profit preclinical contract research organization, today announced its participation in and presentation of scientific data at the Society of Toxicology (SOT) 56th Annual Meeting, held March 12 to 16 in Baltimore.  This announcement comes on the heels of launching Lovelace Biomedical to partner with companies to [...]

A Rich History, An Exciting Future

As you prepare to launch ambitious new projects in 2017, I’d like to personally encourage you to explore the wide array of services and expertise Lovelace Biomedical provides in toxicology, pharmacology, formulation and more. While Lovelace is the same not-for-profit CRO you’ve always known—with a deep history of excellence in respiratory research—today, we offer much [...]

Lovelace Biomedical to showcase expertise in inhalation drug delivery as hosts of the International Society of Aerosols in Medicine Congress

The Lovelace Respiratory Research Institute, including the commercially-focused CRO arm Lovelace Biomedical, has been a leader in inhalation drug delivery, respiratory disease and development of aerosol formulations for more than 40 years.  This year, Lovelace will showcase this broad expertise as the host organization for the 21st Congress of the International Society for Aerosols in […]

Lovelace Biomedical Welcomes Larry Mallis, Ph.D. as Director of Bioanalytical Operations and Further Expands Bioanalytical Chemistry Capabilities

Lovelace Biomedical welcomes Dr. Larry Mallis as Director of Bioanalytical Operations and a key member of the scientific leadership team.  Larry received his Ph.D. in Analytical Chemistry and Mass Spectrometry from Texas A & M University and is a 30 year veteran of analytical chemistry and mass spectrometry in the pharmaceutical and agrochemical industries.  He […]

Addressing the Preclinical Development Challenges of Gene Therapy

While the concept of gene therapy has been around for decades, gene therapy companies are just beginning to convert the promise of gene therapy into reality for patients suffering from a variety of rare diseases and cancer, among others.  The gene therapy industry went into dormancy after a high profile patient death in 1999 but […]

European Style Housing of Nonhuman Primates

In the United States, laboratory animal research requirements are defined by a combination of the Animal Welfare Act Regulations (AWAR), PHS Policy, and the performance standards promulgated in The Guide to the Care and Use of Laboratory Animals or its agricultural counterpart. While The Guide is in use by numerous academic and biomedical research institutions [...]

Reflections on the state of the CRO Industry

Mimicking the decade-long trend of consolidation in the pharmaceutical industry, the past two years have seen a series of major mergers and acquisitions among preclinical CROs.  LabCorp procured Covance; Harlan and Huntingdon Life Sciences merged to form Envigo; and this year WIL Research was acquired by Charles River.  This recent era of consolidation has been […]