Webinar: New Tools to Advance CNS Drug Delivery
Did you miss our webinar with Aptar Pharma? Our Senior Scientist Phil Kuehl, PhD, and our colleague from Aptar, Julie D. Suman, R.Ph., Ph.D, presented on “New Tools to Advance CNS Drug Delivery,” in a live webinar yesterday (July 17, 2019). However, if you missed it, you can still watch the presentation via the following links:
New Tools to Advance CNS Drug Delivery
Currently, there are more than 30 companies involved in the development of therapeutics for delivery to the brain via nasal deposition. Central nervous system (CNS) therapeutic indications include, but are not limited to, anxiety, epilepsy, Alzheimer’s disease, Parkinson’s disease, migraine, multiple sclerosis and depression. In the treatment of depression, for example, nearly 300 million people of all ages, globally, are affected by major depressive disorder (MDD) and have not responded adequately to traditional therapies. Now a new esketamine nasal spray treatment has received FDA approval for MDD with imminent risk for suicide, which demonstrates continued applications for the safe and effective use of nasal sprays for these conditions. CNS diseases represent a huge emotional, financial and social burden to patients, their families, health care providers and society. As our populations continue to age, Alzheimer’s and Parkinson’s may affect more than 50 million people globally. In the USA alone, Alzheimer’s treatments rose to $259 USD billion in 2017. While the demand for CNS drug delivery is evident, there are currently few proven formulations, delivery systems and non-clinical models to evaluate CNS administration.
This webinar will focus on the advantages of nasal powder formulations and on a non-human primate (NHP) model to quantify nose-to-brain delivery of a model compound, sumatriptan. The webinar will also compare pharmacokinetic advantages of nasal powders versus aqueous formulations, as well as in vitro results of nasal powder delivery.
We will also present results from a non-human primates (NHP) cross-over study performed in cynomologus macaques. This study focused on systemic and cerebral spinal fluid (CSF) drug concentrations of sumatriptan administered nasally from a dry powder device, a liquid aerosol device and via subcutaneous delivery. A model was successfully developed to quantify CSF delivery with data that suggests that the NHP model can be used to evaluate nasal delivery as a non-clinical model.
Using the methodology described above, we will demonstrate that a nasal powder increased the extent of absorption in the systemic circulation and CSF. Join us to explore the available opportunities for nasal drug deliveries in CNS medications.