Toxicology News: Comparative effects of parent and heated cinnamaldehyde on the function of human iPSC-derived cardiac myocytes
Lovelace Biomedical collaborated with an American Heart Association consortium to research potential cardiovascular impacts of commonly used flavorings from the tobacco/electronic cigarette industry. The NIH funded study evaluated flavoring degradation products and evaluated their impact on human derived cardiac cells. These types of studies help understand the safety and toxicity of chemicals used in e.cigarettes.
Many e-cigarette products contain cinnamaldehyde as a primary constituent of cinnamon flavorings. When used
as a food additive, cinnamaldehyde is generally regarded as safe for ingestion. However, little is known about
the effects of cinnamaldehyde or its degradation products, generated after heating and inhalation, which may
lead to elevated circulatory exposure to the heart. Hence, in this study, we tested the in vitro cardiac toxicity
of cinnamaldehyde and its thermal degradation products generated by heating at low (200±50°C) and high
temperatures (700±50°C) on the contractility, rhythmicity and electrical signaling properties of human induced
pluripotent stem cell derived cardiac myocytes (hiPSC-CMs).
See the published article here: https://www.sciencedirect.com/science/article/abs/pii/S0887233318308178