Respiratory Health Research; Novel Cough Count Methods by Lovelace Published in Public Library of Science
Cough is an important respiratory defense mechanism [1, 2] and one of the most common symptoms in clinical complaints . Both cough number and sound have been clinically used to evaluate cough sensitivity and intensity [4–13]. In addition, the analysis of cough acoustic differences (frequency, duration and amplitude) has been applied to discriminate cough patterns, especially in diagnosis of human pulmonary diseases and guidance of the relevant therapies [12, 14–18]. Although the animal cough model has been widely employed in cough pathophysiology and therapy, the current recording/analysis system applied in the model obviously has an unmet requirement for the sufficient determination of cough severity and discrimination of cough pattern.